I've got a 150 cm x 120 cm project coming up that I want 300 dpi. I did a few experiments initially doing it at 25% of the final size at 300 dpi and then using enlarging software (in this case Alien Skin Blowup Photoshop plugin) to bring it up to the final size. It seems to work quite well at retaining the brush detail.
Mind you I will have to work with a small brush when doing the 25% original as the brushwork will look way too big and not realistic on the final copy if I don't.
Hope this helps
Frank
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